Content Official Master's Degree in Erasmus Mundus in Human Diseases Models Morphological Phenotyping (MorphoPHEN)
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Knowledge
- Understand the mechanisms that control mouse embryonic processes.
- Identify and understand the shape, structure, arrangement, and relationships of mouse organs.
- Identify mouse tissues and organs microscopically.
- Understand the fundamental principles of mouse pathology and identify organ structural abnormalities by histology and immunohistochemistry. Understand the anatomical basis for diagnostic imaging of the mouse.
- Recognize the basic principles of radiological protection, anaesthesia, and mouse handling.
- Understand the principles of the most relevant preclinical imaging techniques and their application in biomedicine.
- Understand the fundamental principles and recognize the main tools established for deep learning.
- Understand the ethical (3Rs), quantitative and improvement in reproducibility (ARRIVE) aspects in animal experimentation.
- Specific knowledge related to the objective and content of the master's thesis.
Skills
- Correctly use anatomical, pathological, imaging, and deep learning terminology.
- Perform dissection and necropsy of a mouse correctly.
- Interpret data, image processing and post-processing techniques for the different preclinical imaging modalities.
- Apply imaging knowledge to accurately demonstrate through images the anatomy and structure of all mouse organs.
- Use deep learning architectures in real problems, including detection and recognition of patterns on images and 1D signals, diagnosis, and decisions.
- Apply quantitative statistical methods to the design of experiments with mice.
- Writing a research article: extracting key information from the existing bibliography, planning, and structuring a manuscript.
Competences
- Ability to integrate mouse morphology through the organic, cellular, and subcellular levels.
- Ability to correlate structural alterations of mouse organs with specific pathological processes.
- Ability to compare different imaging methodologies and choose the most appropriate for a specific mouse phenotypic analysis.
- Ability to evaluate the performance of deep learning methods.
- Ability to correctly design experiments with mice.
- Being able to design a research plan on the different mouse morphological phenotyping methodologies, describing the definition of the problem, the hypothesis, the research objectives, and the research questions in relation to the relevant literature.